Department of Dermatology,
Venerology and Allergology
Charité – Universitätsmedizin
Berlin

Characterization of sunscreens

Research topics:

Ex vivo determination of the protection efficiency of sunscreens in the UV, visible and IR spectral ranges of the sun radiation (determination of the universal sun protection factor USPF), analysis of the homogeneity of the distribution of sunscreen formulations on human skin under in vivo conditions (factor of inhomogeneity), optimization of the antioxidant content of cosmetic formulations, determination of the efficiency of the sunscreens against the formation of free radicals in human skin; determination of optical properties of sunscreens.

Methods:

Sunscreen
Investigation of in vivo sunscreen distribution by fluorescence marker
  • Tape stripping combined with spectroscopic measurements
  • In vivo laser scanning microscopy
  • In vivo and in vitro EPR spectroscopy
  • Integrating sphere UV-VIS-NIR-spectroscopy, Monte Carlo simulations
  • Resonance Raman spectroscopy
  • In vivo Raman micro-Spectroscopy
sunscreen
Sum transmission of a sunscreen in the UVB and
UVA spectral ranges

 

 

Publications:

M.E. Darvin, H. Richter, S. Ahlberg, S.F. Haag, M.C. Meinke, D. Le Quintrec, O. Doucet, J. Lademann. Influence of sun exposure on the cutaneous collagen/elastin fibers and carotenoids: negative effects can be reduced by application of sunscreen. Journal of Biophotonics, 7(9): 735-743, 2014.

F. Kluschke, H.J. Weigmann, S. Schanzer, M. C. Meinke, T. Vergou, W. Sterry, J. Lademann (2014). Gain or loss? Sunscreen efficiency after cosmetic pretreatment of the skin. Skin Pharm Physiol, 27: 82-89.

M.C. Meinke, F. Syring, S. Schanzer, S.F. Haag, R. Graf, M. Loch, I. Gersonde, N. Groth, F. Pflücker, J. Lademann (2013). Radical protection by differently composed creams in the UV/VIS and IR spectral ranges. Photochem Photobiol, 89: 1079–1084.

T. Vergou, A. Patzelt, S. Schanzer, M.C. Meinke, H.-J. Weigmann, G. Thiede, W. Sterry, J. Lademann, M.E. Darvin (2013). Application of optical methods for the evaluation of the protective efficacy of sunscreen products. Skin Pharmacol Physiol, 26: 30-35.

V. Gebauer, H.-J. Weigmann, S. Schanzer, M. C. Meinke, T. Vergou, W. Sterry, J. Lademann (2012). Influence of skin aging effects on the skin surface profile and the correlated distribution of topically applied sunscreens. J Biophotonics, 5 (3): 274-282.

M.E. Darvin, J.W. Fluhr, S. Schanzer, H. Richter, A. Patzelt, M.C. Meinke, L. Zastrow, K. Golz, O. Doucet, W. Sterry, J. Lademann (2011). Dermal carotenoid level and kinetics after topical and systemic administration of antioxidants: Enrichment strategies in a controlled in vivo study. J Dermatol Sci, 64 (1): 53-58.

M.E. Darvin, J.W. Fluhr, M.C. Meinke, L. Zastrow, W. Sterry, J. Lademann (2011). Topical beta-carotene protects against infra-red-light induced free radicals. Exp Dermatol, 20 (2): 125-129.

M.C. Meinke, S.F. Haag, S. Schanzer, N. Groth, I. Gersonde, J. Lademann (2011). Radical Protection by Sunscreens in the Infrared Spectral Range. Photochem Photobiol, 87(2): 452-456.

M.E. Darvin, W. Sterry, J. Lademann (2010). Resonance Raman spectroscopy as an effective tool for the determination of antioxidative stability of cosmetic formulations. J Biophotonics, 3 (1-2): 82-88.

H.-J. Weigmann, S. Schanzer, A. Patzelt, V. Bahaban, F. Durat, W. Sterry, J. Lademann (2009). Comparison of human and porcine skin for characterization of sunscreens. J Biomed Opt, 14 (2): 024027-1-024027-6.

H.-J. Weigmann, S. Schanzer, A. Teichmann, F. Durat, C. Antoniou, H. Schaefer, W. Sterry, J. Lademann (2007). Ex-vivo spectroscopic quantification of sunscreen efficacy - proposal of a universal sun protection factor. J Biomed Opt, 12 (4): 044013-044021.

H.-J. Weigmann, U. Jacobi, C. Antoniou, G. Tsikrikas, V. Wendel, C. Rapp, H. Gers-Barlag, W. Sterry, J. Lademann (2005). Determination of penetration profiles of topically applied substances by means of tape stripping and optical spectroscopy UV filter substance in sunscreens. J Biomed Opt, 10 (1), 014009.

A.P. Popov, A.V. Priezzhev, J. Lademann, R. Myllylä (2005). TiO2 nanoparticles as effective UV-B radiation skin-protective compound in sunscreens. J Phys D: Appl Phys, 38 (15): 2564-2570.

J. Lademann, S. Schanzer, H. Richter, R. v. Pelchrzim, L. Zastrow, K. Golz, W. Sterry (2004). Sunscreen application behaviour of people on beaches. J Cosmet Dermat, 3: 62-68.