Department of Dermatology,
Venerology and Allergology
Charité – Universitätsmedizin
Berlin

Skin treatment with tissue-tolerable electrical plasma

Research topics:

Application of tissue-tolerable plasma at low temperature for disinfection of human skin, stimulation of the penetration of topically applied substances, stimulation of wound healing processes, safety assessment of the application of tissue-tolerable plasma under in vivo conditions, influence of the plasma treatment on the antioxidative properties the cellular structure of human skin

Methods:

Desinfektion
Application of a tissue-tolerable plasma for skin desinfection
  • Application of tissue-tolerable plasma
  • In vivo laser scanning microscopy
  • Bacterial and mycotic analysis of the skin
  • Raman micro-spectroscopy
  • Resonance Raman spectroscopy
Agar Platte
Identification of bacteria on agar plate

 

Publications:

M. Klebes, C. Ulrich , F. Kluschke, A. Patzelt , S. Vandersee , H. Richter, A. Bob, J. von Hutten , J. Krediet, A. Kramer , J. Lademann, B. Lange-Asschenfeldt (2014).
Combined antibacterial effects of tissue-tolerable plasma and a modern conventional liquid antiseptic on chronic wound treatment.
J Biophotonics, DOI: 10.1002/jbio.201400007

S. Vandersee, J. Lademann, H. Richter, A. Patzelt, B. Lange-Asschenfeldt (2013).
Comparison of tissue damage caused by various laser systems with tissue tolerable plasma by light and laser scan microscopy.
Las Phys Lett, 10: 105602.

J. Lademann, A. Patzelt, H. Richter, O. Lademann, G. Baier, L. Breucker, K. Landfester (2013).
Nanocapsules for drug delivery through the skin barrier by tissue-tolerable plasma.
Laser Phys Lett, 10: 083001.

J. Lademann, C. Ulrich, A. Patzelt, H. Richter, F. Kluschke, M. Klebes, O. Lademann, A. Kramer, K.-D. Weltmann, B. Lange-Asschenfeldt (2013).
Risk assessment of the application of tissue-tolerable plasma on human skin.
Clinical Plasma Med, 1: 5-10.

A. Kramer, J. Lademann, C. Bender, A. Sckell, B. Hartmann, S. Münch, P. Hinz, A. Ekkernkamp, R. Matthes, I. Koban, I. Partecke, C. D. Heidecke, K. Masur, S. Reuter, K.-D. Weltmann, S. Koch, O. Assadian (2013).
Suitability of tissue tolerable plasmas (TTP) for the management of chronic wounds.
Clinical Plasma Medicine, 1: 11-18.

J. Lademann, H. Richter, S. Schanzer, A. Patzelt, G. Thiede, A. Kramer, K.-D. Weltmann, B. Hartmann, B. Lange-Asschenfeldt (2012).
Comparison of the antiseptic efficacy of tissue-tolerable plasma and an octenidine hydrochloride-basedwound antiseptic on human skin.
Skin Pharmacol Physiol, 25: 100-106.

J. W. Fluhr, S. Sassning, O. Lademann, M. E. Darvin, S. Schanzer, A. Kramer, H. Richter, W. Sterry, J. Lademann (2012).
In vivo skin treatment with tissue-tolerable plasma influences skin physiology and antioxidant profile in human stratum corneum.
Exp Dermatology, 21: 130-134.

O. Lademan, H. Richter, M. Meinke, A. Patzelt, A. Kramer, P. Hinz, K.-D. Weltmann, B. Hartmann, S. Koch (2011).
Drug delivery through the skin barrier enhanced by plasma tissue interaction.
Exp Dermatology, 20: 488-490.

O. Lademann, A. Kramer, H. Richter, A. Patzelt, M.C. Meinke, V. Czaika, K.-D. Weltmann, B. Hartmann, S. Koch (2011).
Skin disinfection by plasma tissue interaction: Comparison of the effectivity of tissue tolerable plasma and a standard antiseptic.
Skin Pharmacol Physiol, 24: 284-288.

O. Lademann, H. Richter, A. Kramer, A. Patzelt, M.C. Meinke, C. Graf, Q. Gao, E. Korotianskiy, E. Rühl, K.-D. Weltmann, J. Lademann, S. Koch (2011).
Stimulation of the penetration of particles into the skin by plasma tissue interaction.
Laser Phys Lett, 8 (10): 758-764.

J. Lademann, H. Richter, A. Alborova, D. Humme, A. Patzelt, A. Kramer, K.-D. Weltmann, B. Hartmann, C. Ottomann, J. W. Fluhr, P. Hinz, G. Hübner, O. Lademann (2009).
Risk assessment of the application of a plasma jet in dermatology.
J Biomed Opt, 14 (5): 054025-1-054025-6.

O. Lademann, H. Richter, A. Patzelt, A. Alborova, D. Humme, K.-D. Weltmann, B. Hartmann, P. Hinz, A. Kramer, S. Koch (2010).
Application of a plasma-jet for skin antisepsis: Analysis of the thermal action of the plasma by laser scanning microscopy.
Laser Phys Lett, 7 (6): 458-462.

O. Lademann, A. Kramer, H. Richter, A. Patzelt, M.C. Meinke, J. Röwert-Huber, V. Czaika, K.-D. Weltmann, B. Hartmann, S. Koch (2010).
Antisepsis of the follicular reservoir by treatment with tissue-tolerable plasma (TTP).
Laser Phys Lett, 8 (4): 313-317.

J. W. Fluhr, S. Sassning, O. Lademann, M.E. Darvin, S. Schanzer, A. Kramer, H. Richter, W. Sterry, J. Lademann (2011).
The influence of skin treatment with tissue tolerable plasma on the antioxidant concentration in human skin.
Exp Dermatol, 21 (2): 130-134.

O. Lademann, A. Kramer, H. Richter, A. Patzelt, M. Meinke, V. Czaika, K.-D. Weltmann, B. Hartmann, S. Koch (2011).
Skin disinfection by plasma tissue interaction: Comparison of the effectivity of tissue tolerable plasma and a standard antiseptic.
Skin Pharmacol Physiol, 24 (5): 284-288.

O. Lademann, H. Richter, M. Meinke, A. Patzelt, A. Kramer, K.-D. Weltmann, J. Lademann (2011).
Drug delivery through the skin barrier enhanced by treatment with tissue-tolerable plasma.
Exp Dermatol, 20 (6): 488-490.

O. Lademann, H. Richter, A. Kramer, A. Patzelt, M. C. Meinke, C. Graf, Q. Gao, E. Korotianskiy, E. Ruehl, K.-D. Weltmann, J. Lademann, S. Koch (2011).
Stimulation of the penetration of particles into the skin by plasma tissue interaction.
Laser Phys Lett, 8 (10): 758-764.