Department of Dermatology,
Venerology and Allergology
Charité – Universitätsmedizin

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Intercellular and follicular penetration of topically applied substances

Research topics:

Intercellular and follicular penetration of topically applied substances, penetration kinetics, lateral spreading, storage and action of topically applied drugs.


Cyanoacrylate biopsy Microscopic image of a cyanoacrylate biopsy
Tape stripping penetration profile of a sunscreen


J. Lademann, F. Knorr, H. Richter, S. Jung, M.C. Meinke, E. Rühl, U. Alexiev, M. Calderon, A. Patzelt
Hair follicles as a target structure for nanoparticles
Journal of Innovative Optical Health Sciences 2015; 8(4): 1530004

A. Patzelt, J. Lademann
Drug delivery to hair follicles
Expert Opinion on Drug Discovery 2013; 10(6): 787-797

M. Ulmer, A. Patzelt, T. Vergou, H. Richter, G. Müller, A. Kramer, W. Sterry, V. Czaika, J. Lademann
In vivo investigation of the efficiency of a nanoparticle-emulsion containing polihexanide on the human skin
European Journal of Pharmaceutics and Biopharmaceutics 2013; 84: 325-329

W. C. Mak, A. Patzelt, H. Richter, R. Renneberg, K. K. Lei, E. Rühl, W. Sterry, J. Lademann
Triggering of drug release of particles in hair follicles
Journal of Controlled Release 2012; 160: 509-514

A. Patzelt, H. Richter, F. Knorr, U. Schäfer, C.-M. Lehr, L. Dähne, W. Sterry, J. Lademann
Selective follicular targeting by modification of the particle sizes
Journal of Controlled Release 2011; 150: 45-48

J. Lademann, H. Richter, M. Meinke, W. Sterry, A. Patzelt
Which skin model is the most appropriate for the investigation of topically applied substances into the hair follicles?
Skin Pharmacology and Physiology 2010; 23: 47-52

J. Lademann, A. Patzelt, H. Richter, C. Antoniou, W. Sterry, F. Knorr
Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles
Journal of Biomedical Optics 2009; 14(2): 021014-1-4

A. Patzelt, F. Knorr, U. Blume-Peytavi, W. Sterry, J. Lademann
Hair follicles, their disorders and their opportunities
Drug Discovery Today: Disease Mechanisms 2008; 5(2): 173-181

N. Otberg, A. Patzelt, U. Rasulev, T. Hagemeister, M. Linscheid, R. Sinkgraven, W. Sterry, J. Lademann
The role of hair follicles in the percutaneous absorption of caffeine
British Journal of Clinical Pharmacology 2008; 65(4): 488-492

A. Patzelt, H. Richter, R. Buettemeyer, H.J. Roewert Huber, U. Blume-Peytavi, W. Sterry, J. Lademann
Differential stripping demonstrates a significant reduction of the hair follicle reservoir in vitro compared to in vivo
European Journal of Pharmaceutics and Biopharmaceutics 2008; 70: 234-238