Department of Dermatology,
Venerology and Allergology
Charité – Universitätsmedizin

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Inside-out penetration

Research topics:

Mechanism of appearance of systemically applied substances on human skin; recovery of antioxidants on the skin surface; systemic sun protection; inverse drug delivery; pathomechanism of palmo-plantar erythrodysaesthesia; prevention of cutaneous side effects after systemic application of drugs (e. g., chemotherapy).


Doxurubicin Schweißdrüse
Sweat gland with doxorubicin
  • In vivo laser scanning microscopy
  • Raman micro-spectroscopy
  • Resonance Raman spectroscopy
  • Two-photon microscopy
  • Mass spectroscopy
  • High-pressure liquid chromatography
  • Ion mobility spectrometry
  • X-ray spectroscopy
Laser scanning microscopic examination of a clinical patient



J. Lademann, H. J. Rowert-Huber, N. Haas, F. Kluschke, A. Patzelt, L. Zastrow, B. Lange-Asschenfeldt, S. Jung, W. Sterry, J. Sehouli (2014).
Palmoplantar erythrodysesthesia-like skin symptoms in patients under various chemotherapeutics. Preventive and therapeutic options.
Skin Pharmacol Physiol, 27: 228-232.

J. Lademann, A. Martschick, F. Kluschke, H. Richter, J. W. Fluhr, A. Patzelt , S. Jung, R. Chekerov, M. E. Darvin, N. Haas, W. Sterry, L. Zastrow, J. Sehouli (2014).
Efficient prevention strategy against the development of a palmar-plantar erythrodysesthesia during chemotherapy.
Skin Pharmacol Physiol, 27: 66-70.

J. W. Fluhr, P. Caspers, J.A. van der Pol, H. Richter, W. Sterry, J. Lademann, M.E. Darvin (2011).
Kinetics of carotenoid distribution in human skin in vivo after exogenous stress: Disinfectant and wIRA-induced carotenoid depletion recovers from outside to inside.
J Biomed Opt, 16 (3): 035002.

A. Martschick, J. Sehouli, A. Patzelt, H. Richter, U. Jacobi, G. Oskay-Ozcelik, W. Sterry, J. Lademann (2009).
The pathogenetic mechanism of anthracycline –induced palmar-plantar erythrodysesthesia.
Anticancer Res, 29 (6): 2307-2313.

J. Lademann, P.J. Caspers, A. van der Pol, H. Richter, A. Patzelt, L. Zastrow, M. Darvin, W. Sterry, J.W. Fluhr (2009).
In vivo Raman spectroscopy detects increased epidermal antioxidative potential with topically applied carotenoids.
Laser Phys Lett, 6 (1): 76-79.

A. Patzelt, C. Antoniou, W. Sterry, J. Lademann (2008).
Skin penetration from the inside to the outside: A review. Drug Discov Today Dis Mech,
5 (2): 229-235.

U. Jacobi, J. Bartoll, W. Sterry, J. Lademann (2005).
Orally administered ethanol: Transepidermal pathways and effects on the human skin barrier.
Arch Dermatol Res, 296: 332-338.

J. Lademann, A. Martschick, U. Jacobi, H. Richter, M. Darvin, J. Sehouli, G. Oskay-Özcelik, J.-U. Blohmer, W. Lichtenegger, W. Sterry (2005).
Investigation of doxorubicin on the skin: A spectroscopic study to understand the pathogenesis of PPE.
J Clin Oncol, 23 (16S, Suppl. 1): 5093.

T. Schmook, U. Jacobi, J. Lademann, M. Worm, E. Stockfleth (2005).
Detection of doxorubicin in the horny layer in a patient suffering from palmar-plantar erythrodysaesthesia.
Dermatology, 210 (3): 237-238.

U. Jacobi, E. Waibler, J. Bartoll, P. Schulze, W. Sterry, J. Lademann (2004).
In vivo determination of doxorubicin and its metabolites within the skin using laser scanning microscopy.
Laser Phys Lett, 1 (2), 100-103.

N. Haas, K. Frank, U. Jacobi, W. Katzung, W. Sterry, J. Lademann (2003).
Inside-out Applikation von Ivermectin bei Skabies – eine Hypothese.
JDDG, 12 (1), 933-937.

N. Haas, U. Lindemann, K. Frank, W. Sterry, J. Lademann, W. Katzung (2002).
Rapid and preferential sebum secretion of ivermectin: A new factor that may determine drug responsiveness in patients with scabies.
Arch Derm, 138: 1618-1620.